17 research outputs found
Thermodynamic Computing
The hardware and software foundations laid in the first half of the 20th
Century enabled the computing technologies that have transformed the world, but
these foundations are now under siege. The current computing paradigm, which is
the foundation of much of the current standards of living that we now enjoy,
faces fundamental limitations that are evident from several perspectives. In
terms of hardware, devices have become so small that we are struggling to
eliminate the effects of thermodynamic fluctuations, which are unavoidable at
the nanometer scale. In terms of software, our ability to imagine and program
effective computational abstractions and implementations are clearly challenged
in complex domains. In terms of systems, currently five percent of the power
generated in the US is used to run computing systems - this astonishing figure
is neither ecologically sustainable nor economically scalable. Economically,
the cost of building next-generation semiconductor fabrication plants has
soared past $10 billion. All of these difficulties - device scaling, software
complexity, adaptability, energy consumption, and fabrication economics -
indicate that the current computing paradigm has matured and that continued
improvements along this path will be limited. If technological progress is to
continue and corresponding social and economic benefits are to continue to
accrue, computing must become much more capable, energy efficient, and
affordable. We propose that progress in computing can continue under a united,
physically grounded, computational paradigm centered on thermodynamics. Herein
we propose a research agenda to extend these thermodynamic foundations into
complex, non-equilibrium, self-organizing systems and apply them holistically
to future computing systems that will harness nature's innate computational
capacity. We call this type of computing "Thermodynamic Computing" or TC.Comment: A Computing Community Consortium (CCC) workshop report, 36 page
Summary statistics in auditory perception
Sensory signals are transduced at high resolution, but their structure must be stored in a more compact format. Here we provide evidence that the auditory system summarizes the temporal details of sounds using time-averaged statistics. We measured discrimination of 'sound textures' that were characterized by particular statistical properties, as normally result from the superposition of many acoustic features in auditory scenes. When listeners discriminated examples of different textures, performance improved with excerpt duration. In contrast, when listeners discriminated different examples of the same texture, performance declined with duration, a paradoxical result given that the information available for discrimination grows with duration. These results indicate that once these sounds are of moderate length, the brain's representation is limited to time-averaged statistics, which, for different examples of the same texture, converge to the same values with increasing duration. Such statistical representations produce good categorical discrimination, but limit the ability to discern temporal detail.Howard Hughes Medical Institut
A cross-platform toolkit for mass spectrometry and proteomics
To the Editor:
Mass spectrometry–based proteomics has become an important component of biological research. Numerous proteomics methods have been developed to identify and quantify the proteins in biological and clinical samples1, identify pathways affected by endogenous and exogenous perturbations2 and characterize protein complexes3. Despite successes, the interpretation of vast proteomics data